Tofaretain ER 11

What is Tofaretain ER 11

Tofaretain ER 11 is an extended-release formulation containing Tofacitinib (11 mg), a Janus Kinase (JAK) inhibitor used to manage moderate to severe autoimmune inflammatory conditions. By selectively blocking specific enzymes involved in the body’s immune response, Tofaretain ER 11 helps reduce pain, swelling, and joint stiffness in conditions like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis, offering controlled, once-daily symptomatic relief.

Key Ingredients & Their Role

Tofaretain ER 11 contains the following active component:

• Tofacitinib Citrate I.P. (Equivalent to Tofacitinib 11 mg – Extended Release):

  • JAK Inhibitor Action: Blocks Janus kinase enzymes (JAK1 and JAK3), disrupting intracellular signaling pathways that trigger inflammation and autoimmune tissue damage.

  • Extended Release Mechanism: Formulated to release the medication gradually into the bloodstream, allowing once-daily dosing and maintaining consistent therapeutic levels.

Benefits & What It Helps With

Using Tofaretain ER 11 can help with:

• Reduction of Joint Inflammation: Alleviates joint swelling, tenderness, stiffness, and pain in chronic arthritic conditions.

• Improved Physical Mobility: Enhances joint flexibility and functional mobility, helping patients perform daily activities with greater ease.

• Management of Autoimmune Flare-ups: Controls overactive immune responses and slows disease progression in conditions such as rheumatoid arthritis and ulcerative colitis.

• Once-Daily Convenience: Extended-release delivery system eliminates the need for multiple daily doses.

Who Should Use Tofaretain ER 11

This prescription medicine is generally used by:

• Adults suffering from moderate to severe active Rheumatoid Arthritis who have had an inadequate response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).

• Patients with Psoriatic Arthritis, Ankylosing Spondylitis, or Ulcerative Colitis managed under expert rheumatological or gastroenterological supervision.

Important: Tofaretain ER 11 is a potent prescription medication and must be taken strictly as directed by a specialist physician or rheumatologist.

How to Use & Dosage Advice

• Administration: Swallow the tablet whole with a glass of water. Do not crush, chew, split, or dissolve extended-release tablets, as this alters the controlled-release delivery.

• Food: May be taken with or without food.

• Dosage: Standard dosage is usually 1 tablet once daily, or strictly as prescribed by your treating doctor.

• Regular Monitoring: Periodic blood tests (CBC, liver function, renal function, lipid profile) are recommended during therapy.

Precautions & When to Avoid

• Infections: Avoid initiating during active, serious infections (including tuberculosis, shingles, or systemic fungal infections), as JAK inhibitors lower immune defense.

• Medical Screening: Prior screening for latent tuberculosis (TB) and Hepatitis B/C is necessary before starting treatment.

• Pregnancy & Breastfeeding: Not recommended for use during pregnancy or lactation without strict medical evaluation.

• Precautions: Use caution in patients with a history of blood clots (thrombosis), liver or kidney impairment, or gastrointestinal perforations.

• Vaccinations: Live vaccines should be avoided while taking this medication.

Storage & Handling

• Store in a cool, dry place away from direct sunlight, light, and moisture.

• Keep out of reach of children.

• Packaging: 10x1x10 Alu Alu packaging (10 tablets per strip).

• Always verify the expiry date on the strip before consumption.