Xamigran-500

What is Xamigran-500 Injection

Xamigran-500 Injection is a prescription antifibrinolytic medication containing Tranexamic Acid I.P. (500 mg per 5 ml). It is formulated to control, prevent, and treat excessive bleeding by helping the body slow down the breakdown of blood clots.

Key Ingredients & Their Role

Xamigran-500 contains the following active component:

• Tranexamic Acid I.P. (500 mg / 5 ml):

  • Antifibrinolytic Agent: Reversibly blocks plasminogen binding sites, inhibiting plasmin activation and preventing the degradation of fibrin clots.

  • Hemostatic Control: Helps stabilize blood clots and significantly reduces blood loss during or after surgery, trauma, or medical procedures.

Benefits & What It Helps With

Using Xamigran-500 Injection can help with:

• Control of Surgical & Traumatic Bleeding: Prevents and minimizes heavy blood loss during major surgeries (e.g., orthopedic, cardiac, dental, or gynecological procedures) or physical trauma.

• Management of Heavy Menstrual Bleeding (Menorrhagia): Used under medical supervision to control acute heavy uterine bleeding.

• Prevention of Hemorrhage in Bleeding Disorders: Aids patients with hereditary or acquired bleeding tendencies (e.g., hemophilia) prior to minor surgical interventions like tooth extractions.

• Control of Local Hemorrhages: Helps manage epistaxis (nosebleeds), gastrointestinal bleeding, or hematuria (blood in urine).

Who Should Use Xamigran-500 Injection

This prescription medication is generally indicated for:

• Patients experiencing excessive bleeding or high risk of hemorrhage during or following surgical procedures.

• Individuals requiring rapid hemostatic support for severe medical conditions associated with hyperfibrinolysis.

Important: Xamigran-500 is a prescription medicine (marked Rx) and must be administered strictly under the supervision of a qualified physician or surgeon.

How to Use & Dosage Advice

• Administration Route: For Intravenous (I.V.) Use Only. It should be administered slowly by IV injection or IV infusion by a trained healthcare professional.

• Dosage & Rate: Dosage and administration speed are strictly calculated by the treating physician based on the patient’s body weight, clinical condition, and renal function.

• Hospital/Clinic Setting: Must only be given in a clinical or hospital setting; do not attempt to self-administer.

Precautions & When to Avoid

• Contraindicated in patients with active thromboembolic disease (such as deep vein thrombosis, pulmonary embolism, or cerebral thrombosis) or a history of blood clots.

• Avoid using if you have severe renal impairment, subarachnoid hemorrhage, or known hypersensitivity to Tranexamic Acid.

• Use with caution in patients with mild-to-moderate kidney dysfunction, as dosage adjustments may be necessary.

• Pregnant or breastfeeding women should consult a physician prior to usage.

• Rapid IV injection should be avoided as it may cause transient hypotension (low blood pressure) or dizziness.

Storage & Handling

• Store in a cool, dry place protected from direct light, heat, and moisture.

• Keep out of reach of children.

• Packaging: 5 x 5 ml ampoules packaging.

• Always inspect the solution for clarity and check the expiry date prior to administration.